Generation of a set of induced pluripotent stem cell lines from two Alzheimer disease patients carrying APOE4 (MLUi007-J; MLUi008-A) and healthy old donors carrying APOE3 (MLUi009-A; MLUi010-B) to study APOE in aging and disease


Late-onset Alzheimer disease (LOAD) is the most frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for LOAD. Four human induced pluripotent stem cell (iPSC) lines MLUi007-J, MLUi008-B, MLUi009-A, and MLUi010-B were generated from LOAD patients and healthy matched donors by reprogramming of B-lymphoblastoid cells (B-LCLs) with episomal plasmids. The application of B-LCLs holds a great promise to model LOAD and other diseases because they can easily be generated from primary peripheral blood mononuclear cells (PBMCs) by infection with the Epstein-Barr virus (EBV). Copyright © 2023 Medical Faculty of the Martin Luther University Halle-Wittenberg. Published by Elsevier B.V. All rights reserved.

Authors Jung M, Hartmann C, Ehrhardt T, Peter LM, Abid CL, Harwardt B, Hirschfeld J, Claus C, Haferkamp U, Pless O, Nastainczyk-Wulf M, Kehlen A, Schlote D, Schroder IS, Rujescu D
Journal Stem cell research
Publication Date 2023 Jun;69:103072
PubMed 37001364
DOI 10.1016/j.scr.2023.103072

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