Generation of an IPSC line from a patient with hypertrophic cardiomyopathy carrying a mutation in MYH6 gene
Summary
An induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) of a 41-year-old male patient with hypertrophic cardiomyopathy who carries a G3755A heterozygote mutation in the MYH6 gene. The generated iPSC line expressed pluripotency markers, exhibited a normal karyotype, presented the specific mutation, and demonstrated differentiation potential into three germ layers in vitro. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Wang L, Li X, Fu W, Zhang S, Du W, Zhao J, Liu M, Wang M, Liu Y, Hu L, Ding Z, Li L, Zhao X, Dong J |
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| Journal | Stem cell research |
| Publication Date | 2020 Dec 24;50:102138 |
| PubMed | 33385793 |
| DOI | 10.1016/j.scr.2020.102138 |