Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease
Summary
Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with Parkinson's disease. The non-integrating Sendai virus was used to reprogram iPSCs. iPSCs exhibit pluripotent markers, a normal karyotype, viral clearance, and the ability to differentiate into the three germ layers. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Baek D, Lee KG, Sohn HY, Park JH, Lee HK, Bayarsaikhan G, Yoo SW, Lee B, Kim JS, Koh YH, Kwon M |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Apr;76:103358 |
| PubMed | 38447455 |
| DOI | 10.1016/j.scr.2024.103358 |