Generation of human induced pluripotent stem cell line (MUi033-A) from a male with homozygous for Hemoglobin E
Summary
Hemoglobin E (HbE), a common variant in Southeast Asian populations, results from a G to A substitution at codon 26 of the HBB gene, causing abnormal Hb and mild β-thalassemia-like symptoms. Here, we derived an induced pluripotent stem cell (iPSC) line, named MUi033-A, from a male homozygous for HbE. The iPSC line demonstrates a normal karyotype and embryonic stem cell-like properties including pluripotency gene expression, and tri-lineage differentiation potential. This iPSC resource holds the potential for investigating gene therapy targeting HbE mutation. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Tong-Ngam P, Wongkummool W, Pongpaksupasin P, Rawara N, Kovanich D, Kitiyanant N, Munkongdee T, Paiboonsukwong K, Fucharoen S, Tubsuwan A |
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| Journal | Stem cell research |
| Publication Date | 2023 Dec;73:103228 |
| PubMed | 37890329 |
| DOI | 10.1016/j.scr.2023.103228 |