YAP-depleted iPSC MUSIi012-A-2 maintained all normal stem cell characteristics


Yes-associated protein (YAP) is an important transcriptional coactivator in the Hippo signaling pathway. Using CRISPR/Cas9 technology, we established a stable YAP-knockdown (YAP-KD) induced pluripotent stem cell (iPSC) from the MUSIi012-A cell line. The YAP-KD iPSC MUSIi012-A-2 maintained the pluripotent phenotype, the ability to differentiate into all three embryonic germ layers, and it maintained the normal karyotype. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Lorthongpanich C, Laowtammathron C, Jiamvoraphong N, Srisook P, Chingsuwanrote P, Klaihmon P, Damkham N, Terbto P, Waeteekul S, U-Pratya Y, Issaragrisil S
Journal Stem cell research
Publication Date 2020 Mar;43:101723
PubMed 32018207
DOI 10.1016/j.scr.2020.101723

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