Production and characterization of human induced pluripotent stem cell line (PUMCi002-A) from a Krabbe patient related control to study disease mechanisms associated with GALC mutation
Summary
A KD-control human induced pluripotent stem cells (iPSCs) line (PUMCi002-A) was generated from dermal fibroblasts of a Krabbe patient's father with a c.461C>A mutation in Galactocerebrosidase (GALC) gene. The pluripotency, in vitro differentiation potential and karyotype stability of generated iPSC line were analyzed and confirmed. This cell line can be exploited as a control iPSC line to better understand the mechanisms involved in GALC-associated Krabbe disease and provide plausible new therapeutic directions. Copyright © 2022. Published by Elsevier B.V.
| Authors | Lv YF, Wang J, Cao CY, Zhang Y, Wang W |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Dec;65:102945 |
| PubMed | 36270068 |
| DOI | 10.1016/j.scr.2022.102945 |