Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood
Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD-) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD- sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD- somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
|Authors||Kim J, Koh H, Zhen X, Lee DS, Ha HY, Lee JH|
|Journal||Stem cell research|
|Publication Date||2021 Jan 26;51:102199|