Establishment of iPSC (KRIBBi001-A) from CD34(+) group O D-negative bone marrow blood


Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD-) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD- sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD- somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Kim J, Koh H, Zhen X, Lee DS, Ha HY, Lee JH
Journal Stem cell research
Publication Date 2021 Mar;51:102199
PubMed 33529979
DOI 10.1016/j.scr.2021.102199

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