A heterozygous MYBPC3 (c. 772+1G > A) mutant human induced pluripotent stem cell line (ZZUNEUi025-A) generated from a male patient with hypertrophic cardiomyopathy
Summary
Hypertrophic cardiomyopathy (HCM) is the most common heterogeneous myocardial disease. MYBPC3 variants are the leading cause of HCM. In the present study, a human induced pluripotent stem cell (iPSC) line ZZUNEUi025-A was generated from peripheral blood mononuclear cells of a male HCM patient with c. 772+1G > A in MYBPC3 gene. This cell line expressed pluripotency markers, had normal male karyotype and could differentiate into three germ layers in vitro. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Zhao X, Cao J, Li X, Liu M, Liu Y, Dong J, Zhao X |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Apr;60:102722 |
| PubMed | 35257994 |
| DOI | 10.1016/j.scr.2022.102722 |