Lack of population diversity in commonly used human embryonic stem-cell lines
Summary
We determined the genetic ancestry of a large collection of stem-cell lines. We have found that widely distributed stem-cell lines lack population diversity and that none of these lines derive from populations with recent African ancestry. Efforts to derive and disseminate new stem-cell lines should now emphasize underrepresented poplulations, to allow researchers to assess the extent to which the ancestry of stem -cell lines influences disease models, cellular therapies, and drug screeening with the use of stem cells.
| Authors | Mosher JT, Pemberton TJ, Harter K, Wang C, Buzbas EO, Dvorak P, Simón C, Morrison SJ, Rosenberg NA |
|---|---|
| Journal | The New England journal of medicine |
| Publication Date | 2010 Jan 14;362(2):183-5 |
| PubMed | 20018958 |
| DOI | 10.1056/nejmc0910371 |