Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation
Summary
We established an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome, carrying heterozygous c.290 + 1G > A mutation in STK11 gene. Peripheral blood mononuclear cells were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL and c-MYC. The iPSC line expressed pluripotency markers, could differentiate into cells of three germ layers in vitro, and displayed a normal karyotype. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Wang T, Zhu K, Yu W, Peng L, Wang H, Wu Q |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Sep;71:103152 |
| PubMed | 37392704 |
| DOI | 10.1016/j.scr.2023.103152 |