Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation


We established an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome, carrying heterozygous c.290 + 1G > A mutation in STK11 gene. Peripheral blood mononuclear cells were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL and c-MYC. The iPSC line expressed pluripotency markers, could differentiate into cells of three germ layers in vitro, and displayed a normal karyotype. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Wang T, Zhu K, Yu W, Peng L, Wang H, Wu Q
Journal Stem cell research
Publication Date 2023 Sep;71:103152
PubMed 37392704
DOI 10.1016/j.scr.2023.103152

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