Human embryonic stem cell lines derived from single blastomeres of two 4-cell stage embryos
Summary
We report the successful derivation and characterization of two hESC lines from single blastomeres of four split 4-cell stage human embryos. These two hESC lines were derived from distinct embryos, proving that at least one of the 4-cell stage blastomeres is pluripotent.
| Authors | Geens M, Mateizel I, Sermon K, De Rycke M, Spits C, Cauffman G, Devroey P, Tournaye H, Liebaers I, Van de Velde H |
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| Journal | Human reproduction (Oxford, England) |
| Publication Date | 2009 Nov;24(11):2709-17 |
| PubMed | 19633307 |
| PubMed Central | PMC2763129 |
| DOI | 10.1093/humrep/dep262 |