Human embryonic stem cell lines derived from single blastomeres of two 4-cell stage embryos


We report the successful derivation and characterization of two hESC lines from single blastomeres of four split 4-cell stage human embryos. These two hESC lines were derived from distinct embryos, proving that at least one of the 4-cell stage blastomeres is pluripotent.

Authors Geens M, Mateizel I, Sermon K, De Rycke M, Spits C, Cauffman G, Devroey P, Tournaye H, Liebaers I, Van de Velde H
Journal Human reproduction (Oxford, England)
Publication Date 2009 Nov;24(11):2709-17
PubMed 19633307
PubMed Central PMC2763129
DOI 10.1093/humrep/dep262

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