Generation of normal induced pluripotent stem cell line KUMCi002-A from bone marrow CD34+ cells of patient with multiple myeloma disease having 13q deletion and IGH translocation


Multiple myeloma (MM) is a hematological cancer characterized by an uncontrolled proliferation of antibody-secreting plasma cells within the bone marrow. Currently, cell therapy such as chimeric antigen receptor T-cell (CAR-T) based on induced pluripotent stem cells (iPSCs) has received attention for treating MM. However, the generation of iPSCs from MM patients appears to be very rarely reported. Here we generated an iPSC line from CD34+ bone marrow cells of a patient with MM using human placenta-derived cell conditioned medium (hPCCM), offering a relatively high efficiency in humanized conditions. This iPSC line might be a useful model for research on MM. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Lee SJ, Kim JH, Kang KW, Lee BH, Kim BS
Journal Stem cell research
Publication Date 2020 Dec;49:102030
PubMed 33142253
DOI 10.1016/j.scr.2020.102030

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