Generation of two induced pluripotent stem cell lines from breast cancer patients carrying BRCA2 variants


Germline pathogenic variants in the BRCA2 gene are strongly correlated with an elevated risk of developing breast cancer. Two specific BRCA2 variants, c.8167G>C (p.Asp2723His) and c.1583del (p.Asn528fs), have been identified from individuals with a family history of breast cancer. Here we generated two iPSC lines from breast cancer patients who are heterozygous carriers of these two variants. These iPSCs exhibit pluripotency and demonstrate the capability to differentiate into three germ layers. These iPSC lines represent a valuable resource for personalized pre-clinical research, offering new opportunities to explore the underlying mechanisms of breast cancer and develop targeted therapeutic approaches. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Zhang M, Liu W, Li A, Htet MH, Yu R, Telli ML, Wu JC
Journal Stem cell research
Publication Date 2023 Oct;72:103219
PubMed 37816281
PubMed Central PMC10902209
DOI 10.1016/j.scr.2023.103219

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