Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)
Summary
X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC. Established iPSC lines expressed various pluripotency markers, had differentiation potential of three germ layers in vitro, had normal karyotype and retained ABCD1 mutation. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Son D, Quan Z, Kang PJ, Park G, Kang HC, You S |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2017 Dec;25:46-49 |
| PubMed | 29065337 |
| DOI | 10.1016/j.scr.2017.10.003 |