Human induced pluripotent stem cells line (PNUSCRi002-A) from a patient with Parkinson's disease carrying a R159W mutation in the GBA gene
Summary
Mutation in the glucocerebrosidase encoding gene 1 (GBA) is one of the most frequent causes of Parkinson's disease (PD). Herein, we obtained peripheral blood mononuclear cells (PBMCs) from a patient with PD with a heterozygous c.475C > T (p.R159W) mutation in the GBA gene, and generated an induced pluripotent stem cell (iPSC) line (GBA PD9 or PNUSCRi002-A hiPSCs) using a non-integrative Sendai virus. The iPSC line expressed pluripotency markers (OCT4, NANOG, SSEA-4, TRA-1-60) and displayed differentiation properties in the three germ layers (ectoderm, endoderm, and mesoderm). Additionally, the patient had a normal karyotype. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Moon HJ, Lee N, Moon JY, Park KK, Lee JH, Kim JH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Dec;65:102948 |
| PubMed | 36274270 |
| DOI | 10.1016/j.scr.2022.102948 |