Generation of induced pluripotent stem cell lines (RFSCi003-A, RFSCi004-A) from monozygotic twins discordant for age-related macular degeneration
Summary
Age-related macular degeneration (AMD) has significant genetic component, yet monozygotic twins frequently exhibit discordance in disease status, highlighting the role of non-genetic factors. To enable comparative studies of AMD pathogenesis, we generated two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of a monozygotic twin pair discordant for AMD. These iPSC lines offer a unique genetically matched resource to investigate molecular differences between affected and unaffected twins, as well as their responses to genetic, epigenetic, and environmental contributors to AMD development. Copyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Rajendran N, Runyon W, Hu S, Singh A, Ratnapriya R, Kumar R, Csaky K, Sripathi SR |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Jul 5;87:103768 |
| PubMed | 40627958 |
| DOI | 10.1016/j.scr.2025.103768 |