Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient


Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system where the main pathogenetic events include demyelination and axonal degeneration. Here, we generated a human induced pluripotent stem cell (hiPSC) line from peripheral blood mononuclear cells of an MS patient utilizing Sendai virus reprogramming. The produced hiPSC line expressed pluripotency markers, differentiated into three germ layers, showed a normal karyotype and was free of virus vectors, transgenes and mycoplasma. Established hiPSCs are a valuable source for studies of MS disease modeling and drug discovery. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Lotila J, Hyvärinen T, Skottman H, Airas L, Narkilahti S, Hagman S
Journal Stem cell research
Publication Date 2022 Aug;63:102865
PubMed 35843021
DOI 10.1016/j.scr.2022.102865

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