Generation of integration-free Down syndrome and isogenic euploid human induced pluripotent stem cells


A pair of Down syndrome (DS) human iPSCs (hiPSCs) and isogenic euploid hiPSCs generated by using an integration-free Sendai viral vector system showed trisomy 21 (47; XY) and typical (46; XY) karyotype respectively. Pluripotency of both hiPSC lines was confirmed by pluripotency marker expression and three germ layer differentiation potentials. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Nehra S, Sharma V, Umrani M, Singhal N
Journal Stem cell research
Publication Date 2023 Mar;67:103041
PubMed 36764067
DOI 10.1016/j.scr.2023.103041

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