Generation of an induced pluripotent stem cell (iPSC) line (EXSURGi001-A) from a patient homozygous for the p.Ala165Thr mutation in the MTARC1 gene
Summary
Metabolic dysfunction-associated fatty liver disease (MAFLD), the leading cause of end-stage liver disease in developed countries, is expected to increase over the next decade. Characterized by hepatic steatosis, MAFLD is commonly studied in animal models. Here, we generated a human induced pluripotent stem cell (iPSC) line from a patient homozygous of the protective MTARC1 gene variant rs2642438:A. This line displays a normal karyotype and typical pluripotent stem cell morphology and can differentiate into all three germ layers in vitro. Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Tang P, Keshi E, Wilken S, Wutsdorff L, Mougnekabol J, Pratschke J, Sauer IM, Haep N |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Oct;80:103516 |
| PubMed | 39094505 |
| DOI | 10.1016/j.scr.2024.103516 |