CB1D

The cell line is not validated yet.

General

Cell Line

hPSCreg name UCLi009-A
Cite as:
UCLi009-A (RRID:CVCL_VF13)
Alternative name(s)
CB1D
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
UCLi009-B
(CB1E)
Donor's gene variants:
VCP
Donor diseases:
Frontotemporal dementia
UCLi010-A
Donor's gene variants:
VCP
Donor diseases:
Frontotemporal dementia
UCLi010-B
(GL1B)
Donor's gene variants:
VCP
Donor diseases:
Frontotemporal dementia
LUBi001-A
(PGRN-8310, PGRN8310, RCi195, RCFB58 c12.5)
Donor's gene variants:
GRN, GRN, GRN, GRN
Donor diseases:
Frontotemporal dementia
LUBi001-B
(PGRN-8310, RCFB58 c4.4, PGRN8310, RCi194)
Donor's gene variants:
GRN, GRN, GRN, GRN
Donor diseases:
Frontotemporal dementia
LUBi001-C
(PGRN-8310, RCFB58 c3.7, RCi200, PGRN8310)
Donor's gene variants:
GRN, GRN, GRN, GRN
Donor diseases:
Frontotemporal dementia
UCLi004-A
(RCi173, RCFB60c6)
Donor's gene variants:
C9orf72, C9orf72
Donor diseases:
Amyotrophic lateral sclerosis
Frontotemporal dementia
UCLi004-B
(RCFB60c7, RCi177)
Donor's gene variants:
C9orf72, C9orf72
Donor diseases:
Amyotrophic lateral sclerosis
Frontotemporal dementia
UCLi004-C
(RCi172, RCFB60c2)
Donor's gene variants:
C9orf72, C9orf72
Donor diseases:
Amyotrophic lateral sclerosis
Frontotemporal dementia
UCLi003-A
(TSM(exon10+16)V97)
Donor's gene variants:
MAPT
Donor diseases:
Frontotemporal dementia
UCLi001-A
(HHItC9S-V19)
Donor's gene variants:
C9orf72
Donor diseases:
Frontotemporal dementia
UCLi002-A
(HHItC9D-V34, DN19)
Donor's gene variants:
C9orf72, C9orf72
Donor diseases:
Frontotemporal dementia
STBCi253-A
(SFC184-01-04)
Donor diseases:
migraine disorder
STBCi255-A
(SFC183-01-07)
Donor diseases:
migraine disorder
STBCi257-A
(SFC185-01-11)
Donor diseases:
migraine disorder
STBCi260-A
(SFC279-03-02)
Donor diseases:
migraine disorder
STBCi261-A
(SFC186-01-07)
Donor diseases:
migraine disorder
STBCi262-A
(SFC271-03-06)
Donor diseases:
migraine disorder
STBCi263-A
(SFC268-03-02)
Donor's gene variants:
ATP1A2
Donor diseases:
migraine disorder
STBCi055-C
(SFC026-04-04)
Donor diseases:
migraine disorder
STBCi027-A
(SFC017-03-01)
Donor diseases:
migraine disorder
STBCi027-B
(SFC017-03-02)
Donor diseases:
migraine disorder
STBCi028-A
(SFC018-03-01)
Donor diseases:
migraine disorder
STBCi028-B
(SFC018-03-02)
Donor diseases:
migraine disorder
STBCi028-C
(SFC018-03-04)
Donor diseases:
migraine disorder
STBCi029-A
(SFC020-03-02)
Donor diseases:
migraine disorder
STBCi029-B
(SFC020-03-03)
Donor diseases:
migraine disorder
STBCi030-A
(SFC023-03-24)
Donor diseases:
migraine disorder
STBCi030-B
(SFC023-03-43)
Donor diseases:
migraine disorder
STBCi031-A
(SFC024-04-02)
Donor diseases:
migraine disorder
STBCi031-B
(SFC024-04-03)
Donor diseases:
migraine disorder
ZZUi014-A
(ZZU-iPS-SCA3-002)
Donor diseases:
Spinocerebellar ataxia type 3
STBCi031-C
(SFC024-04-01)
Donor diseases:
migraine disorder
STBCi141-A
(SFC103-03-01)
Donor diseases:
migraine disorder
STBCi055-A
(SFC026-04-03)
Donor diseases:
migraine disorder
STBCi055-B
(SFC026-04-10)
Donor diseases:
migraine disorder
WTSIi568-A
(HPSI0216i-rihx_4)
Donor diseases:
Hereditary ataxia
CHDIi001-A
(#1c8, CHDI-90002149)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
ZZUi010-A
(ZZU-iPS-AD-APP-001)
Donor diseases:
obsolete_Alzheimer's disease
CHDIi003-A
(#3c1, CHDI-90002151)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi005-A
(#5c4, CHDI-90002153)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
ZZUi009-A
(ZZU-iPS-AD-PS1-001)
Donor diseases:
obsolete_Alzheimer's disease
CHDIi010-A
(#10c2, CHDI-90002158)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi020-A
(#20c2, CHDI-90002168)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi022-A
(#22c1, CHDI-90002170)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi026-A
(#26c3, CHDI-90002174)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi029-A
(#29c4, CHDI-90002177)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi031-A
(#31c1, CHDI-90002179)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi033-A
(#104c2, CHDI-90002181)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
Last update 22nd May 2019
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Provider

Generator University College London (UCL)
Owner University College London (UCL)
Distributors
Derivation country United Kingdom

External Databases

BioSamples SAMEA4675625
Cellosaurus CVCL_VF13
Wikidata Q54989678

General Information

Publications
* Is the cell line readily obtainable for third parties?
Yes
Research use: allowed
Clinical use: allowed
Commercial use: allowed

Donor Information

General Donor Information

Sex female

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is a carrier of a disease-associated mutation.
Synonyms
  • FTD
Genetic variants
VCP (target)
R155C
Heterozygous
Is the medical history available upon request? No
Is clinical information available? No

Karyotyping (Donor)

Has the donor karyotype been analysed?
Yes
46XX

Other Genotyping (Donor)

Is there genome-wide genotyping or functional data available?
No

Donor Relations

Other cell lines of this donor

External Databases (Donor)

BioSamples SAMEA4675626

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? Yes
Provide contact information of the holder of the original Donor Information Sheet:
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? Yes
Contact information / weblink Signed consent forms are held at the UCL Dementia Research Centre
Alternatives to consent are available? No
Alternatives to consent
Alternative consent approval number
Is there other documentation provided to the donor for consenting purposes? No
Confirm that consent was obtained by a qualified professional Yes
Has the donor agreed to be re-contacted? No
Has the donor been informed about how her/his data will be protected? Yes
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent expressly prevent the derivation of pluripotent stem cells? No
Does consent pertain to a specific research project? No
Details on restriction to research project
Does consent permit unforeseen future research, without further consent? No
Does the consent permit uses of donated embryo/tissue or derived cell line intended for clinical treatment or human applications? Yes
Does consent expressly permit storage of donated embryo/tissue for an unlimited time? Yes
Does consent expressly permit storage of cells derived from the donated embryo/tissue for an unlimited time? Yes
Does consent prevent the DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No

Does consent permit research by

an academic institution? Yes
a public organisation? Yes
a non-profit company? Yes
a for-profit corporation? Yes
Does consent expressly permit collection of genetic information? Yes
Does consent expressly permit storage of genetic information? Yes
Does consent prevent dissemination of genetic information? No
Has the donor been informed that their donated biosample or derived cells may be tested for the presence of microbiological agents / pathogens? No
Has the donor consented to receive information discovered during use of donated embryo/tissue that has significant health implications for the donor? No
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Please describe how access is provided:
Contact data, institution, or website:
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? UCLH/National Hospital for Neurology and Neurosurgery Joint Research Ethics Committee
Approval number 09/0272
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the PROPOSED PROJECT, involving use of donated embryo/tissue or derived cells? Yes
Name of accrediting authority involved? UCLH/National Hospital for Neurology and Neurosurgery Joint Research Ethics Committee
Approval number 09/0272
Please describe:
Further constraints on use
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?
Constraints for use or distribution

hIPSC Derivation

General

Source cell type
A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.; These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.

Reprogramming method

Vector type Non-integrating
Vector Episomal

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium Essential 8™

Characterisation

No characterisation data could be found.

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
46XX

Other Genotyping (Cell Line)