GL1B

The cell line is not validated yet.

General

Cell Line

hPSCreg name UCLi010-B
Cite as:
UCLi010-B (RRID:CVCL_VF16)
Alternative name(s)
GL1B
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
UCLi010-A
Donor's gene variants:
VCP
Donor diseases:
Frontotemporal dementia
UCLi009-B
(CB1E)
Donor's gene variants:
VCP
Donor diseases:
Frontotemporal dementia
UCLi009-A
(CB1D)
Donor's gene variants:
VCP
Donor diseases:
Frontotemporal dementia
UCLi002-A
(HHItC9D-V34, DN19)
Donor's gene variants:
C9orf72, C9orf72
Donor diseases:
Frontotemporal dementia
UCLi001-A
(HHItC9S-V19)
Donor's gene variants:
C9orf72
Donor diseases:
Frontotemporal dementia
UCLi003-A
(TSM(exon10+16)V97)
Donor's gene variants:
MAPT
Donor diseases:
Frontotemporal dementia
UCLi004-C
(RCi172, RCFB60c2)
Donor's gene variants:
C9orf72, C9orf72
Donor diseases:
Amyotrophic lateral sclerosis
Frontotemporal dementia
LUBi001-A
(PGRN-8310, PGRN8310, RCi195, RCFB58 c12.5)
Donor's gene variants:
GRN, GRN, GRN, GRN
Donor diseases:
Frontotemporal dementia
LUBi001-B
(PGRN-8310, RCFB58 c4.4, PGRN8310, RCi194)
Donor's gene variants:
GRN, GRN, GRN, GRN
Donor diseases:
Frontotemporal dementia
LUBi001-C
(PGRN-8310, RCFB58 c3.7, RCi200, PGRN8310)
Donor's gene variants:
GRN, GRN, GRN, GRN
Donor diseases:
Frontotemporal dementia
UCLi004-A
(RCi173, RCFB60c6)
Donor's gene variants:
C9orf72, C9orf72
Donor diseases:
Amyotrophic lateral sclerosis
Frontotemporal dementia
UCLi004-B
(RCFB60c7, RCi177)
Donor's gene variants:
C9orf72, C9orf72
Donor diseases:
Amyotrophic lateral sclerosis
Frontotemporal dementia
UKBi001-B
Donor's gene variants:
ATXN3
Donor diseases:
Machado-Joseph disease
CSSi001-A
(Joub03cl2, COR419)
Donor diseases:
Joubert syndrome
UKBi003-A
(iLB-MJD1-32m-r9, LB-32-r9)
Donor's gene variants:
ATXN3, ATXN3
Donor diseases:
Machado-Joseph disease
UKBi008-A
(iLB-MJD4-34m-r1, LB-34-1)
Donor's gene variants:
ATXN3, ATXN3
Donor diseases:
Machado-Joseph disease
UOXFi003-A
(MK088-1)
Donor's gene variants:
GBA1
Donor diseases:
Parkinson disease
UOXFi003-C
(MK088-7)
Donor's gene variants:
GBA1
Donor diseases:
Parkinson disease
CSSi004-A
(HD256.05 cl1)
Donor diseases:
Huntington disease
UGOTSAi002-B
(N1-001iC2)
Donor diseases:
Alzheimer's Disease
UGOTSAi003-A
(N1-002iC3A)
Donor diseases:
Alzheimer's Disease
UGOTSAi003-B
(N1-002iC4)
Donor diseases:
Alzheimer's Disease
UGOTSAi006-A
(N1-005iC1)
Donor diseases:
Alzheimer's Disease
ESi049-A
(MS FiPS 2 R4F-10)
Donor diseases:
obsolete_multiple sclerosis
FINi002-A
(FI.CPLT.PRKN.R275W+del_e8.PK006)
Donor's gene variants:
PRKN
Donor diseases:
Parkinson Disease
UOXFi010-C
(JR023-5)
Donor diseases:
Parkinson disease
UKBi007-A
(LB-33-5, iLB-MJD3-33f-r5)
Donor's gene variants:
ATXN3, ATXN3
Donor diseases:
Machado-Joseph disease
Last update 22nd May 2019
User feedback
No feedback available yet.

Login to share your feedback, experiences or results with the research community.

Provider

Generator University College London (UCL)

External Databases

BioSamples SAMEA4675630
Cellosaurus CVCL_VF16
Wikidata Q54989681

General Information

Publications
* Is the cell line readily obtainable for third parties?
Yes
Research use: allowed
Clinical use: allowed
Commercial use: allowed

Donor Information

General Donor Information

Sex male

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is a carrier of a disease-associated mutation.
Synonyms
  • FTD
Genetic variants
VCP (target)
R191Q
Heterozygous

Donor Relations

Other cell lines of this donor

External Databases (Donor)

BioSamples SAMEA4675629

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? Yes
Please provide contact information of the holder of the original Donor Information Sheet.
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? Yes
Please provide the contact information Signed consent forms are held at the Dementia Research Centre UCL
Alternatives to consent
Alternative consent approval number
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent expressly prevent the derivation of pluripotent stem cells? No
Details on restriction to research project
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Please describe how access is provided:
Contact data, institution, or website:
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? UCLH Research Ethics Committee
Approval number 09/0272
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the PROPOSED PROJECT, involving use of donated embryo/tissue or derived cells? Yes
Name of accrediting authority involved? UCLH Research Ethics Committee
Approval number 09/0272
Please describe:
Further constraints on use
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?
Constraints for use or distribution

hIPSC Derivation

General

Source cell type
Any skin fibroblast that is part of some dermis.

Reprogramming method

Vector type Non-integrating
Vector Episomal

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium Essential 8™

Characterisation

No characterisation data could be found.

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
46XY

Other Genotyping (Cell Line)