Generation of an induced pluripotent stem cell (iPSC) line from a diabetic patient with glucagon receptor (GCGR) p.W83X mutation


Induced pluripotent stem cell (iPSC) line, SJHi001-A, was generated from a diabetic patient carrying a heterozygous c.G248A mutation in GCGR gene that generated the p.W83X. The PBMCs from her father (no diabetes and no mutation site) were also prepared into iPSC (SJHi002-A) as a control. Both two cell lines had normal karyotype, expressed pluripotency markers and could differentiate into the three germ layers in vivo. Copyright © 2022. Published by Elsevier B.V.

Authors Liu Y, Liu Y, Jia Y, Lv J, Sun D, Yin Y, Liu N, Su B, Sun G
Journal Stem cell research
Publication Date 2022 May;61:102745
PubMed 35381520
DOI 10.1016/j.scr.2022.102745

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