Generation of iPSC line (GLNNFi001-A) from peripheral blood mononuclear cells of a patient with macular corneal dystrophy
Summary
Macular corneal dystrophy (MCD) an autosomal recessive disorder leading to severe visual impairment is caused by mutations in the carbohydrate sulfotransferase 6 (CHST6) gene. Here, we describe generation of a iPSC line from peripheral blood mononuclear cells (PBMCs) from a 38 year old MCD patient harboring a homozygous mutation, p.V172L in the CHST6 gene. The iPSC line GLNNFi001-A was generated using an integration-free Sendai virus containing (KLF4, c-MYC, OCT4 and SOX2). Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Chakrabarty K, Prashanthi KN, Shetty R, Argulwar S, Jeyabalan N, Ghosh A |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Jul;62:102789 |
| PubMed | 35472829 |
| DOI | 10.1016/j.scr.2022.102789 |