Generation of iPSC line (GLNNFi001-A) from peripheral blood mononuclear cells of a patient with macular corneal dystrophy

Summary

Macular corneal dystrophy (MCD) an autosomal recessive disorder leading to severe visual impairment is caused by mutations in the carbohydrate sulfotransferase 6 (CHST6) gene. Here, we describe generation of a iPSC line from peripheral blood mononuclear cells (PBMCs) from a 38 year old MCD patient harboring a homozygous mutation, p.V172L in the CHST6 gene. The iPSC line GLNNFi001-A was generated using an integration-free Sendai virus containing (KLF4, c-MYC, OCT4 and SOX2). Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Chakrabarty K, Prashanthi KN, Shetty R, Argulwar S, Jeyabalan N, Ghosh A
Journal Stem cell research
Publication Date 2022 Apr 22;62:102789
PubMed 35472829
DOI 10.1016/j.scr.2022.102789

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