A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells


This novel hiPSC-based approach provides a sustainable and homogeneous source for a rapid and highly productive generation of phenotypically mature, functional MCs, and its principle allows for the investigation of disease- and patient-specific MC populations. Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Authors Luo Y, Fernandez Vallone V, He J, Frischbutter S, Kolkhir P, Moñino-Romero S, Stachelscheid H, Streu-Haddad V, Maurer M, Siebenhaar F, Scheffel J
Journal The Journal of allergy and clinical immunology
Publication Date 2022 Mar;149(3):1060-1068.e4
PubMed 34371081
DOI 10.1016/j.jaci.2021.07.027

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