Derivation of Breast Cancer Patient Derived Human Induced Pluripotent Stem Cell Line (YBLi006-A) with FANC-BRCA Gene Mutations: A Resource for Precision & Personalized Medicine
Summary
Fanconi anemia complementation group I (FANCI) is located on the chromosome 15q26.1 locus and becomes ubiquitinated following DNA damage. 3.06% of patients with breast cancer have altered FANCI gene. We generated an iPSC line (YBLi006-A) from peripheral blood mononuclear cells (PBMCs) of a patient carrying a mutation in FANCIgene (NM_001376911.1, NM_001376910.1, NM_001113378.2; c.80G > T, c.257C > T, c.2225G > C; p.Gly27Val, p.Ala86Val, p.Cys742Ser) using non-integrating Sendai virus technology. This unique breast cancer patient-derived-iPSC line will be resourceful to analyze the entire coding sequence and splicing sites ofFANCIin high-risk familial breast cancer. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Chitrangi S, Vaity P, Jamdar A, Sarkar J, Bhatt S |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Aug;70:103128 |
| PubMed | 37290137 |
| DOI | 10.1016/j.scr.2023.103128 |