UMGi270-A-1

Registration Summary:

A P E C

resFLNC, DCM1_res

The cell line is not submitted yet.

(only basic data is shown)

General

Cell Line
hPSCreg name	UMGi270-A-1
Cite as:	UMGi270-A-1
Alternative name(s)	resFLNC, DCM1_res
Cell line type	Human induced pluripotent stem cell (hiPSC)
Similar lines	No similar lines found.
Last update	29th January 2024
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Provider
Generator	University Medical Center Goettingen (UMG)
General Information
Publications	Maurer W et al. Generation of a pluripotent stem cell line (UMGi270-A) and a corresponding CRISPR/Cas9 modified isogenic control (UMGi270-A-1) from a patient with sudden onset dilated cardiomyopathy harboring a FLNC p.R2187P mutation. Stem cell research. 2024 Jun;77:103409. Gerritse Merel et al. Characteristics and pharmacological responsiveness in hiPSC models of inherited cardiomyopathy. Pharmacology & Therapeutics. 2025-08-00. Knierim Maria et al. Atrial fibrillation in end‐stage heart failure: Cellular mechanisms behind CASTLE‐HTx. European Journal of Heart Failure. 2025-09-17.
Subclone of	UMGi270-A

hIPSC Derivation

General
The source cell information can be found in the parental cell line UMGi270-A.