Generation of two induced pluripotent stem cell lines from breast cancer patients carrying BRCA1 mutations
Summary
Haploinsufficiency of BRCA1 increases the risk of various cancers due to its critical functions in cell cycle checkpoint regulation and DNA repair. This study generated and characterized two induced pluripotent stem cell (iPSC) lines derived from breast cancer patients with mutations in the BRCA1 gene (c.676del and c.5096G>A). Both lines exhibited typical iPSC morphology, karyotype, pluripotency marker expression, and trilineage differentiation capabilities. BRCA1-mutated iPSCs provide a valuable resource to investigate pathogenic mechanisms and develop personalized medicine. Copyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Chen YI, Caudal A, Flores-Banuelos AG, Yan CD, Park WG, Viswanathan M, Wu JC |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Aug;86:103716 |
| PubMed | 40286603 |
| PubMed Central | PMC12203875 |
| DOI | 10.1016/j.scr.2025.103716 |