Generation of six induced pluripotent stem cell (iPSC) lines from two patients with amyotrophic lateral sclerosis (NUIGi043-A, NUIGi043-B, NUIGi043-C, NUIGi044-A, NUIGi044-B, NUIGi044-C)


In this study, we generated 6 induced pluripotent stem cell (iPSC) lines derived from dermal fibroblasts of patients with sporadic amyotrophic lateral sclerosis (sALS). The fibroblasts were reprogrammed using non-integrating Sendai viruses containing four reprogramming factors OCT3/4, SOX2, KLF4 and C-MYC. The iPSC lines displayed normal molecular karyotype, expressed pluripotency markers and were capable of differentiating into three embryonic germ layers. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Yang M, Liu M, Vajda A, O'Brien T, Henshall D, Hardiman O, Shen S
Journal Stem cell research
Publication Date 2019 Oct;40:101558
PubMed 31514057
DOI 10.1016/j.scr.2019.101558

Research Projects

Cell Lines