Establishment of a non-integrate iPS cell line (SDQLCHi023-A) from a patient with Xq25 microduplication syndrome carrying a 1.3 Mb hemizygote duplication at chrXq25


Xq25 microduplication syndrome is a recognized syndrome presenting intellectual disability and distinctive facial appearance. We generated an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMCs) of an 8-year-old boy with Xq25 Microduplication Syndrome carrying a 1.3 Mb hemizygote duplication at chrXq25. The iPSCs expressed pluripotency markers, free of genomically integrated episomal plasmids, with normal karyotype and three layers' differentiation potential in vitro. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Yang X, Duan C, Zhang H, Li Y, Guan J, Wang D, Lv Y, Gai Z, Liu Y
Journal Stem cell research
Publication Date 2021 Mar;51:102147
PubMed 33493992
DOI 10.1016/j.scr.2020.102147

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