Karolinska Institutet Human Embryonic Stem Cell Bank

Summary

The Karolinska Institutet Human Embryonic Stem Cell Bank (KI Stem Cell Bank) was established at KI, Stockholm, Sweden, when the first human embryonic stem cell (hESC) line was derived by Professor Hovatta and colleagues in 2002. Since then, the bank has grown to include 60 hESC lines. From the very beginning the aim of the bank has been derivation of hESC lines suitable for clinical use. Step by step progress has been made towards this goal, including removal of xeno components, establishment of chemically defined conditions and Good Manufacturing Practice (GMP) compliancy. Today our bank includes such clinical grade hESC line, KARO1, derived and banked according to GMP guidelines. Many of the hESC lines in the bank have been distributed to the scientific community and are deposited in the Stockholm Medical Biobank available for research on collaborative basis. Copyright © 2020. Published by Elsevier B.V.

Authors Main H, Hedenskog M, Acharya G, Hovatta O, Lanner F
Journal Stem cell research
Publication Date 2020 Apr 21;45:101810
PubMed 32339905
DOI 10.1016/j.scr.2020.101810

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