Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses
Summary
These findings suggest that PLCγ2P522R may result in increased surveillance by microglia, and prime them towards an anti-inflammatory state, with an increased capacity to respond to increasing energy demands, but highlights the delicate balance of this system, with increasing PLCγ2P522R 'dose' resulting in reduced beneficial impacts. © 2022. The Author(s).
| Authors | Solomon S, Sampathkumar NK, Carre I, Mondal M, Chennell G, Vernon AC, Ruepp MD, Mitchell JC |
|---|---|
| Journal | Cellular and molecular life sciences : CMLS |
| Publication Date | 2022 Jul 27;79(8):453 |
| PubMed | 35895133 |
| PubMed Central | PMC9329165 |
| DOI | 10.1007/s00018-022-04473-1 |