Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses


These findings suggest that PLCγ2P522R may result in increased surveillance by microglia, and prime them towards an anti-inflammatory state, with an increased capacity to respond to increasing energy demands, but highlights the delicate balance of this system, with increasing PLCγ2P522R 'dose' resulting in reduced beneficial impacts. © 2022. The Author(s).

Authors Solomon S, Sampathkumar NK, Carre I, Mondal M, Chennell G, Vernon AC, Ruepp MD, Mitchell JC
Journal Cellular and molecular life sciences : CMLS
Publication Date 2022 Jul 27;79(8):453
PubMed 35895133
PubMed Central PMC9329165
DOI 10.1007/s00018-022-04473-1

Research Projects

Cell Lines