A heterozygous MYH7 (c. 2156G > A) mutant human induced pluripotent stem cell line (ZZUNEUi020-A) generated from a patient with hypertrophic cardiomyopathy
Summary
Hypertrophic cardiomyopathy (HCM) is a heterogeneous myocardial disease often caused by sarcomeric gene mutations. MYH7 is one of the most common genes associated with HCM. In this study, we generated a human induced pluripotent stem cell (iPSC) line ZZUNEUi020-A from peripheral blood mononuclear cells of a female HCM patient with the p. R719Q (c. 2156G > A) mutation in MYH7. This cell line expressed pluripotency markers, showed normal female karyotype and could differentiate into all three germ layers in vitro. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Li X, Fu W, Guo G, Liu M, Du W, Zhao J, Liu Y, Wang L, Dong J, Zhao X |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Mar;51:102158 |
| PubMed | 33453578 |
| DOI | 10.1016/j.scr.2021.102158 |