Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation


Mutations in the neurofibromin (NF1) gene cause neurofibromatosis type 1 (NF1), a complex tumour predisposition syndrome. Here, we generated two induced pluripotent stem cell (iPSC) lines using urine cells (UCs) derived from a 21-year-old female NF1 patient carrying c.496_497delGT mutation in the NF1 gene (p.Val166LeufsTer7). The newly derived SMBCi003-A and SMBCi003-B iPSC lines used as a cellular model to unravel pathogenesis of NF1. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Shi L, Cui Y, Qi Z, Zhou X, Luan J, Han J
Journal Stem cell research
Publication Date 2020 Jul;46:101842
PubMed 32554297
DOI 10.1016/j.scr.2020.101842

Research Projects

Cell Lines