Generation of a human induced pluripotent stem cell line (FDCHi010-A) from a patient with Xia-Gibbs syndrome carrying AHDC1 mutation (c.2062C > T)


A human induced pluripotent stem cell line (iPSC), FDCHi010-A, was derived from the peripheral blood of a 3-year-old patient with the c.2062C > T (p.R688*) mutation in the AHDC1 gene. The established cell line displayed a typical human embryonic stem cell-like morphology, exhibited a normal euploid karyotype, and fully expressed pluripotency markers. In addition, it retained the ability to differentiate to three germ layers. This cell line with a specific mutation may provide a useful tool for studying the pathogenesis and drug therapy screening of Xia-Gibbs syndrome caused by the AHDC1 gene. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Yin T, Wu B, Peng T, Liao Y, Jiao S, Wang H
Journal Stem cell research
Publication Date 2023 Jun;69:103118
PubMed 37216737
DOI 10.1016/j.scr.2023.103118

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