Stem cell transplantation as a progressing treatment for retinitis pigmentosa


Retinal degenerative diseases such as retinitis pigmentosa (RP) are of the major causes of vision loss in developed countries. Despite the unclear pathophysiology, treatment methods have been investigated vastly in the past decades. This review article mainly discusses the advances in application of stem cell and progenitor transplantation for retinitis pigmentosa. Stem cell sources such as mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, neural stem cells, retinal progenitor cells, and olfactory ensheathing cells are discussed separately in addition to a brief description of two approaches for treatment of early-stage RP, including gene therapy and nutritional therapy. © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Authors Hosseini Shabanan S, Seyedmirzaei H, Barnea A, Hanaei S, Rezaei N
Journal Cell and tissue research
Publication Date 2022 Feb;387(2):177-205
PubMed 35001210
DOI 10.1007/s00441-021-03551-3

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