Generation of three induced pluripotent stem cells lines from patients with esophageal atresia/tracheoesophageal fistula type C


Esophageal atresia/tracheoesophageal fistula (EA/TEF) is the most common congenital anomaly of the upper gastrointestinal tract affecting 1 in 3,000 which could stem from a developmental anomaly of the foregut. The cause is not fully understood. We generated three iPSC cell lines using peripheral blood mononuclear cells (PBMCs) from EA/TEF type C patients. Pluripotency and trilineage differentiation capacity of these three iPSC cell lines were confirmed by gene and protein expression profiles and the differentiation ability into the three germ layers. The generated disease-specific cell lines could serve as a tool to investigate the mechanisms of EA/TEF and acquired associated diseases. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Raad S, David A, Chung W, Faure C
Journal Stem cell research
Publication Date 2022 Apr;60:102711
PubMed 35193008
PubMed Central PMC10104726
DOI 10.1016/j.scr.2022.102711

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