Generation of a human induced pluripotent stem cell line harboring the infant leukemia-associated fusion gene, KMT2A-AFF1 (IMSUTi002-A-2)
Summary
KMT2A-AFF1 (MLL-AF4), formed by chromosomal translocation t(4;11), is observed specifically in infant pro-B acute lymphoblastic leukemia, and the main driver of leukemogenesis. In this study, a human induced pluripotent stem cell (hiPSC) line harboring KMT2A-AFF1 (IMSUTi002-A-2), which has the ability to simultaneously induce the doxycycline-inducible expression of KMT2A-AFF1 and EGFP, was established. This hiPSC can be a powerful model for understanding infant leukemia and risk assessment of leukemogenesis. Copyright © 2023 The Author. Published by Elsevier B.V. All rights reserved.
| Authors | Takahashi M |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Sep;71:103185 |
| PubMed | 37639801 |
| DOI | 10.1016/j.scr.2023.103185 |