Application prospects of urine-derived stem cells in neurological and musculoskeletal diseases
Summary
Urine-derived stem cells (USCs) are derived from urine and harbor the potential of proliferation and multidirectional differentiation. Moreover, USCs could be reprogrammed into pluripotent stem cells [namely urine-derived induced pluripotent stem cells (UiPSCs)] through transcription factors, such as octamer binding transcription factor 4, sex determining region Y-box 2, kruppel-like factor 4, myelocytomatosis oncogene, and Nanog homeobox and protein lin-28, in which the first four are known as Yamanaka factors. Mounting evidence supports that USCs and UiPSCs possess high potential of neurogenic, myogenic, and osteogenic differentiation, indicating that they may play a crucial role in the treatment of neurological and musculoskeletal diseases. Therefore, we summarized the origin and physiological characteristics of USCs and UiPSCs and their therapeutic application in neurological and musculoskeletal disorders in this review, which not only contributes to deepen our understanding of hallmarks of USCs and UiPSCs but also provides the theoretical basis for the treatment of neurological and musculoskeletal disorders with USCs and UiPSCs. ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
| Authors | Yang HS, Zheng YX, Bai X, He XY, Wang TH |
|---|---|
| Journal | World journal of orthopedics |
| Publication Date | 2024 Oct 18;15(10):918-931 |
| PubMed | 39473520 |
| PubMed Central | PMC11514553 |
| DOI | 10.5312/wjo.v15.i10.918 |