Guidelines for managing and using the digital phenotypes of pluripotent stem cell lines
Summary
Each pluripotent stem cell line has a physical entity as well as a digital phenotype, but linking the two unambiguously is confounded by poor naming practices and assumed knowledge. Registration gives each line a unique and persistent identifier that links to phenotypic data generated over the lifetime of that line. Registration is a key recommendation of the 2023 ISSCR Standards for the use of human stem cells in research. Here we consider how community adoption of stem cell line registration could facilitate the establishment of integrated digital phenotypes of specific human pluripotent stem cell (hPSC) lines. Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
| Authors | Wells CA, Guhr A, Bairoch A, Chen Y, Hu M, Löser P, Ludwig TE, Mah N, Mueller SC, Seiler Wulczyn AEM, Seltmann S, Rossbach B, Kurtz A |
|---|---|
| Journal | Stem cell reports |
| Publication Date | 2024 Oct 8;19(10):1369-1378 |
| PubMed | 39332404 |
| PubMed Central | PMC11561460 |
| DOI | 10.1016/j.stemcr.2024.08.009 |