Induced pluripotent stem cell line derived from a sporadic amyotrophic lateral sclerosis patient


Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) obtained from a 60-year-old female diagnosed with sporadic amyotrophic lateral sclerosis (sALS). The iPSCs shared the same karyotype with the parent PBMCs, expressed pluripotency stem cell markers, and demonstrated trilineage differentiation potential. This cell line could serve as an ideal model to investigate the mechanisms underlying amyotrophic lateral sclerosis (ALS). Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Feng B, Ma J, Amponsah AE, Guo R, Kong D, He J, Jiang Y, Zhang W, Zhang Z, Song Y, Shen S, O'Brien T, Cui H
Journal Stem cell research
Publication Date 2020 May;45:101841
PubMed 32434130
DOI 10.1016/j.scr.2020.101841

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