Induced pluripotent stem cell line derived from a sporadic amyotrophic lateral sclerosis patient
Summary
Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) obtained from a 60-year-old female diagnosed with sporadic amyotrophic lateral sclerosis (sALS). The iPSCs shared the same karyotype with the parent PBMCs, expressed pluripotency stem cell markers, and demonstrated trilineage differentiation potential. This cell line could serve as an ideal model to investigate the mechanisms underlying amyotrophic lateral sclerosis (ALS). Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Feng B, Ma J, Amponsah AE, Guo R, Kong D, He J, Jiang Y, Zhang W, Zhang Z, Song Y, Shen S, O'Brien T, Cui H |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 May;45:101841 |
| PubMed | 32434130 |
| DOI | 10.1016/j.scr.2020.101841 |