Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients


Familial dilated cardiomyopathy (DCM) is among the most prevalent forms of inherited heart disease. Here, two human-induced pluripotent stem cell (iPSC) lines were generated from peripheral blood mononuclear cells (PBMCs) from DCM patients carrying different mutations in the phospholamban encoding-gene (PLN). Both iPSC lines exhibited normal morphology, karyotype, pluripotency marker expression, and differentiation into the three germ layers. These patient-specific iPSC lines serve as valuable in vitro models for DCM pathology caused by PLN mutations. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Caudal A, Mondejar-Parreño G, Vera CD, Williams DR, Shenoy SP, Liang D, Wu JC
Journal Stem cell research
Publication Date 2022 Aug;63:102855
PubMed 35853412
DOI 10.1016/j.scr.2022.102855

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