Generation and cardiac differentiation of an induced pluripotent stem cell line from a patient with arrhythmia-induced cardiomyopathy

Summary

Arrhythmia-induced cardiomyopathy (AIC) is characterized by left-ventricular systolic dysfunction caused by persistent arrhythmia. To date, genetic or pathological drivers causing AIC remain unknown. Here, we generated induced pluripotent stem cells (iPSCs) from an AIC patient. The AIC-iPSCs exhibited full pluripotency and differentiation characteristics and maintained a normal karyotype after reprogramming. The AIC-iPSCs differentiated into functional beating AIC-iPSC-cardiomyocytes (CMs), which represents the cell-type of interest to study molecular, genetic and functional aspects of AIC. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Rebs S, Beier J, Argyriou L, Schill T, Hasenfuss G, Vollmann D, Sossalla S, Streckfuss-Bömeke K
Journal Stem cell research
Publication Date 2021 Feb 20;53:102263
PubMed 33631417
DOI 10.1016/j.scr.2021.102263

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