Derivation of induced pluripotent stem cells (SDUKIi003-A) from a 20-year-old male patient diagnosed with Asperger syndrome


Autism spectrum disorder is a heterogenous neurodevelopmental disorder. The patients experience challenges in social interaction and communication skills as well as restricted and/or repetitive behaviors. To understand the molecular mechanisms underlying developmental brain disorders, patient-derived cellular models represent a useful tool. We have generated a human induced pluripotent stem cell line (SDUKIi003-A) from skin fibroblasts derived from a 20-year old male patient diagnosed with Asperger syndrome ("FYNEN-cohort" of Southern Denmark). The reprogramming of the fibroblasts was accomplished using integration-free episomal plasmids. Characterization validated the expression of pluripotency markers, differentiation into the three germ layers, and absence of chromosomal abnormalities. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Kamand M, Ilieva M, Louise Forsberg S, Thomassen M, Meyer M, Fex Svenningsen Å, Maria Michel T
Journal Stem cell research
Publication Date 2020 Oct;48:101974
PubMed 32916638
DOI 10.1016/j.scr.2020.101974

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