Generation of induced pluripotent stem cell lines IRMBi003-A and IRMBi003-B from a healthy donor to model Alzheimer's disease


Induced Pluripotent Stem Cell (iPSC) lines derived from healthy individuals are helpful and essential tools for disease modelling. Here, we described the reprogramming of skin fibroblasts obtained from a healthy 59-year-old individual without Alzheimer's disease. The generated iPSC lines have a normal karyotype, expressed pluripotency markers, and demonstrated the ability to differentiate into the three germ layers. The iPSC lines will be used as controls to study Alzheimer's disease mechanisms. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Clua Provost C, Auboyer L, Rovelet-Lecrux A, Monzo C, Schob E, Andreux F, Quittet C, Lehmann S, Wallon D, Crozet C
Journal Stem cell research
Publication Date 2023 Dec;73:103250
PubMed 37979430
DOI 10.1016/j.scr.2023.103250

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