Generation of a human induced pluripotent stem cell line from a Bietti crystalline corneoretinal dystrophy patient with CYP4V2 mutations
Summary
Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessively inherited progressive retinal disease. Here, we describe the generation and characterization of a human induced pluripotent stem cell (hiPSC) line of BCD patient with CYP4V2 mutations. The reprogramming of this iPSC line was performed from skin fibroblast by using the Sendai-virus based approach. The established hiPSC line retained the disease-associated mutations and showed normal karyotype, pluripotency and differentiation capacity. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Wu S, Zhu T, Sun Z, Wei X, Han X, Zou X, Sui R |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 May;53:102330 |
| PubMed | 33857831 |
| DOI | 10.1016/j.scr.2021.102330 |