Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis


Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated human induced pluripotent stem cells (hiPSCs) from four COVID-19 patients, all characterized by increased levels of high-sensitivity Troponin I (hsTnI) during the infection acute phase, who developed (n = 2) or not (n = 2) severe myocarditis, as COVID-19 complication. The established hiPSCs were characterized for pluripotency and genomic stability, and constitute a useful resource for studying the mechanisms underlying the variability in COVID-19 severe cardiac manifestations. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Rabino M, Rurali E, Zamboni C, Rovina D, Mallia S, Cauteruccio M, Baggiano A, Giacari CM, Bellin M, Pompilio G
Journal Stem cell research
Publication Date 2023 Mar;67:103018
PubMed 36630840
PubMed Central PMC9812822
DOI 10.1016/j.scr.2023.103018

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