SMYD1 modulates the proliferation of multipotent cardiac progenitor cells derived from human pluripotent stem cells during myocardial differentiation through GSK3β/β-catenin&ERK signaling
Summary
Our research indicated that the participation of SMYD1 in the GSK3β/β-catenin&ERK signaling cascade modulated the proliferation of cardiac progenitor cells during myocardial differentiation. This process was partly reliant on the transcription of GSK3β. Our research provided a novel insight into the genetic modification effect of SMYD1 during early myocardial differentiation. The findings were essential to the molecular mechanism and potential interventions for congenital heart disease. © 2024. The Author(s).
| Authors | Chang Y, Bai R, Zhang Y, Lu WJ, Ma S, Zhu M, Lan F, Jiang Y |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2024 Oct 8;15(1):350 |
| PubMed | 39380045 |
| PubMed Central | PMC11462858 |
| DOI | 10.1186/s13287-024-03899-7 |