Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome

Summary

Monosomy of chromosome X is associated with high prenatal mortality of female embryos and severe developmental abnormalities of patients born with Turner's syndrome (45,XO). The CDMLe012-A-1 human embryonic stem cell (hESC) line, derived from a day six blastocyst with a normal 46,XX female karyotype spontaneously lost an X-chromosome during cell culture. This 45,XO karyotype was stably maintained for more than 55 passages. Since the CDMLe012-A-1 cells express pluripotent stem cell markers and differentiate into cells derived from the three germ layers, the cell line represents a stable, pluripotent stem cell model of Turner's syndrome. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Domozhirov AY, Mazzilli JL, Wetsel RA, Zsigmond EM
Journal Stem cell research
Publication Date 2019 Jul 23;39:101508
PubMed 31357114
DOI 10.1016/j.scr.2019.101508

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