TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes
Summary
In summary, TAB2 abatement cardiomyocytes mimic dilated cardiomyopathy in vitro. This finding emphasizes the importance of using a human model to study the underlying mechanisms of this specific disease. More importantly, the discovery of a unique pathogenic pathway introduces a new notion for the future management of dilated cardiomyopathy. © 2025. The Author(s).
| Authors | Sun W, Zhang J, Li S, Fu W, Liu Y, Liu M, Dong J, Zhao X, Li X |
|---|---|
| Journal | Molecular medicine (Cambridge, Mass.) |
| Publication Date | 2025 Feb 4;31(1):42 |
| PubMed | 39905300 |
| PubMed Central | PMC11792723 |
| DOI | 10.1186/s10020-025-01103-x |