Generation of three induced pluripotent stem cell lines to model and investigate diseases affecting Hispanics
Summary
Hispanics are the fastest-growing minority group in the United States. There has been a burgeoning interest in understanding the reasons underlying health disparities among this population. To facilitate the modeling and investigation of diseases that differentially impact Hispanics, we generated three induced pluripotent stem cell (iPSC) lines from the peripheral blood mononuclear cells (PBMCs) of healthy Hispanic subjects. All three lines exhibited normal morphology and karyotypes, robust expression of pluripotency markers, and the capacity for trilineage differentiation. The derivatives of these lines will serve as valuable ethnic-appropriate cell sources for further mechanistic studies on diseases impacting Hispanics. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Chen IY, Olshausen J, Thomas D, Lai C, McLaughlin TL, Wu JC |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Dec;65:102969 |
| PubMed | 36427473 |
| PubMed Central | PMC10082602 |
| DOI | 10.1016/j.scr.2022.102969 |